Gene interactions and pathways from curated databases and text-mining

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TNFRSF1A — TRAF2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Devin et al., Immunity 2000 : The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1 : TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
Terry Powers et al., Biochemistry 2010 : Collectively, these data suggest that ( i ) the interaction between TNF-R1 and TRAF2 requires sequences located in the entire N-terminal half ( residues 1-440 ) of TRUSS, ( ii ) the binding interface for TNF-R1 is closely linked with the TRAF2 binding interface, and ( iii ) the assembly of homomeric TRUSS complexes may contribute to its role in TNF-R1 signaling