◀ Back to TRAF2
TNFRSF1A — TRAF2
Pathways - manually collected, often from reviews:
-
BioCarta sodd/tnfr1 signaling pathway:
SODD (BAG4)
→
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
MADD
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
→
TRAF2
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
TNF/TNF R/TRAF2/ASK1/RIP complex (TNFRSF1A-TRAF2-MAP3K5-RIPK1-TNF)
→
TNF R/TRAF2/ASK1/RIP complex (TNFRSF1A-TRAF2-MAP3K5-RIPK1)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
TNF/TNF R/TRAF2/ASK1/RIP complex (TNFRSF1A-TRAF2-MAP3K5-RIPK1-TNF)
→
TNF R (TNFRSF1A)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
TNF R/TRAF2/ASK1/RIP complex (TNFRSF1A-TRAF2-MAP3K5-RIPK1)
→
TNF R (TNFRSF1A)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 2 (active) (CASP2)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 2 (CASP2)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
JNKK1 (MAP2K4)
(modification, activates)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
MAP4K2
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
FADD
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
FADD/Caspase 8 complex (CASP8-FADD)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 8 (CASP8)
(modification, activates)
-
BioCarta tnf/stress related signaling:
SODD (BAG4)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRAF2
→
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRAF2
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRADD
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
I-TRAF (TANK)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
Caspase 2 (CASP2)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
MADD
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
SODD (BAG4)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TRAF2
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
SODD (BAG4)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TRADD
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
MADD
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TRAF2
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TRAF1
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
RAIDD (CRADD)
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
SODD (BAG4)
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
ASK1 (MAP3K5)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TRADD
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TRAF2
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
Caspase 2 (CASP2)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
FADD
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TRAF2
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
KEGG Apoptosis:
TNFRSF1A
→
Complex of RIPK1-TRADD-TRAF2
(protein-protein, activation)
-
KEGG Osteoclast differentiation:
TNFRSF1A
→
TRAF2/TRAF6
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
TNFRSF1A
→
TRAF2
(protein-protein, activation)
-
KEGG Hepatitis C:
TNFRSF1A
→
Complex of TRADD-TRAF2
(protein-protein, binding/association)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, activates)
Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
RAIDD (CRADD)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FADD (FADD)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
ASK1 (MAP3K5)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TRAF1 (TRAF1)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
cIAP2 (BIRC3)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
BAG4 (BAG4)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
Caspase 2 (CASP2)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A)
→
TRAF2 (TRAF2)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
TRADD (TRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
TRAF2 (TRAF2)
(modification, collaborate)
-
NCI Pathway Database TNF receptor signaling pathway :
FADD (FADD)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
FADD (FADD)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Atypical PKCs (PRKCI/PRKCZ)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Atypical PKCs (PRKCI/PRKCZ)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
p62 (SQSTM1)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
p62 (SQSTM1)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
Boldin et al., Cell 1996, Muzio et al., Cell 1996
Evidence: assay
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
NIK (MAP3K14)
(modification, activates)
Malinin et al., Nature 1997
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
STAT1 (STAT1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (CASP8)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
MEKK3 (MAP3K3)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
→
MEKK3 (MAP3K3)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
RFFL (RFFL)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
TRX/ASK1 complex (MAP3K5-TXN)
(modification, activates)
Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
thioredoxin (TXN)
(modification, activates)
Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Caveolin-1 (CAV1)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
(translocation, activates)
Schütze et al., J Biol Chem 1999, D'Alessio et al., Am J Pathol 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
→
NF kappa B1/RelA complex (NFKB1-RELA)
(modification, activates)
Sanz et al., EMBO J 1999, Leitges et al., Mol Cell 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
RIP (RIPK1)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
RIP (RIPK1)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
A20 (TNFAIP3)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
None
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, inhibits)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Neutral sphingomyelinase II (SMPD3)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
Cathepsin D/ceramide complex (CTSD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Heinrich et al., Cell Death Differ 2004
Evidence: assay
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Acid Sphingomyelinase (SMPD1)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
cIAP1 (BIRC2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Devin et al., Immunity 2000, Yang et al., Nat Immunol 2001, Ducut Sigala et al., Science 2004, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (CASP8)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Caspase 8 (CASP8)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, inhibits)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD/PIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF-PIDD1)
→
Caspase 2 (CASP2)
(modification, activates)
-
NCI Pathway Database Ceramide signaling pathway:
cIAP2 (BIRC3)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRAF2 (TRAF2)
→
TNFR1A/BAG4/TNF-alpha complex (TNFRSF1A-BAG4-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRAF2 (TRAF2)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
BAG4 (BAG4)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
RAIDD (CRADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRADD (TRADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
RIP (RIPK1)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
MADD (MADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TNFR1A/BAG4/TNF-alpha complex (TNFRSF1A-BAG4-TNF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
Reactome Reaction:
TNFRSF1A
→
TRAF2
(reaction)
Harper et al., J Biol Chem 2003*, Micheau et al., Cell 2003, Hsu et al., Cell 1995
-
Reactome Reaction:
TNFRSF1A
→
TRAF2
(indirect_complex)
Hsu et al., Cell 1995
-
WikiPathways Apoptosis:
Complex of TNFRSF21-TNFRSF1B-TNFRSF25-TRADD-TNFRSF10B-TNFRSF1A
→
TRAF3/TRAF1/TRAF2
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Vince et al., Cell 2007*
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Zheng et al., Mol Cell Biol 2006*
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Kolliputi et al., Am J Respir Cell Mol Biol 2009*
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Lee et al., J Cell Physiol 2010*
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Park et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Kim et al., Mol Cell Biol 2005*
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Hsu et al., Immunity 1996
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Hsu et al., Cell 1996
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Shu et al., Proc Natl Acad Sci U S A 1996
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Vince et al., J Biol Chem 2009*
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Mahul-Mellier et al., Cell Death Differ 2012
-
IRef Biogrid Interaction:
TNFRSF1A
—
TRAF2
(physical association, affinity chromatography technology)
Won et al., Cell Death Differ 2010*
-
MIPS CORUM Tumor necrosis factor receptor 1 signaling complex:
Tumor necrosis factor receptor 1 signaling complex complex (BIRC2-TNFRSF1A-TRADD-TRAF2)
Shu et al., Proc Natl Acad Sci U S A 1996
-
IRef Hprd Interaction:
Complex of 50 proteins
(in vivo)
Micheau et al., Cell 2003
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Micheau et al., Cell 2003
-
IRef Hprd Interaction:
TNFRSF1A
—
TRAF2
(in vivo)
Hsu et al., Cell 1996
-
IRef Intact Interaction:
Complex of BIRC2-RIPK1-TRADD-TNFRSF1A-TNF-TRAF2
(association, anti tag coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti tag coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of TRAF2-TRADD-TNFRSF1A
(association, anti bait coimmunoprecipitation)
Zheng et al., Mol Cell Biol 2006*
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti bait coimmunoprecipitation)
Shu et al., Proc Natl Acad Sci U S A 1996
-
IRef Ophid Interaction:
TNFRSF1A
—
TRAF2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Devin et al., Immunity 2000
:
The distinct roles of TRAF2 and RIP in IKK
activation by
TNF-R1 :
TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
Terry Powers et al., Biochemistry 2010
:
Collectively, these data suggest that ( i ) the interaction between TNF-R1 and
TRAF2 requires sequences located in the entire N-terminal half ( residues 1-440 ) of TRUSS, ( ii ) the binding interface for TNF-R1 is closely linked with the TRAF2 binding interface, and ( iii ) the assembly of homomeric TRUSS complexes may
contribute to its role in
TNF-R1 signaling