Gene interactions and pathways from curated databases and text-mining

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EGF — TNS3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of BCAR1-PTK2-TNS3 → EGF (decreases, BCAR1/PTK2/TNS3 Activity) Cui et al., Mol Cancer Res 2004*
    Evidence: Furthermore, tensin3 forms a complex with focal adhesion kinase and p130Cas in MDA-MB-468 cells. Addition of EGF to the cells induces dephosphorylation of these two molecules, leads to disassociation of the tensin3-focal adhesion kinase-p130Cas complex, and enhances the interaction between tensin3 and EGF receptor.
  • OpenBEL Selventa BEL large corpus: Complex of EGFR-TNS3 → EGF (increases) Cui et al., Mol Cancer Res 2004*
    Evidence: Addition of EGF to the cells induces dephosphorylation of these two molecules, leads to disassociation of the tensin3-focal adhesion kinase-p130Cas complex, and enhances the interaction between tensin3 and EGF receptor.
  • OpenBEL Selventa BEL large corpus: TNS3 → EGF (increases, EGF Activity, TNS3 Activity) Cui et al., Mol Cancer Res 2004*
    Evidence: Furthermore, tensin3 forms a complex with focal adhesion kinase and p130Cas in MDA-MB-468 cells. Addition of EGF to the cells induces dephosphorylation of these two molecules, leads to disassociation of the tensin3-focal adhesion kinase-p130Cas complex, and enhances the interaction between tensin3 and EGF receptor.