Gene interactions and pathways from curated databases and text-mining

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EGFR — TRAF1

Text-mined interactions from Literome

Webster-Cyriaque et al., J Virol 2000 (AIDS-Related Opportunistic Infections...) : Effects induced by activated TRAF signaling that were detected in HLP included activation of NF-kappaB and c-Jun terminal kinase 1 (JNK1) and upregulated expression of epidermal growth factor receptor (EGFR) , CD40, A20, and TRAFs
Wang et al., Zhonghua Zhong Liu Za Zhi 2001 (Nasopharyngeal Neoplasms) : Overexpression of either TRAF1 , 3 or an dominant negative mutant of TRAF1, 3 inhibited the expression of EGFR , while TRAF2 or negative mutants of TRAF2 did slightly so
Miller et al., Mol Cell Biol 1998 : In vivo analyses of the interaction of the TRAFs with LMP1 variants mutated in the PXQXT domain indicate that high-level induction of EGFR expression requires interaction with TRAF1 , -2, and -3 ... These data suggest that TRAF mediated activation of EGFR expression requires assembly of a complex containing the appropriate stoichiometry of TRAF proteins clustered at the cell membrane with LMP1