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EGFR — TRAF1
Text-mined interactions from Literome
Webster-Cyriaque et al., J Virol 2000
(AIDS-Related Opportunistic Infections...) :
Effects
induced by activated
TRAF signaling that were detected in HLP included activation of NF-kappaB and c-Jun terminal kinase 1 (JNK1) and upregulated expression of
epidermal growth factor receptor (EGFR) , CD40, A20, and TRAFs
Wang et al., Zhonghua Zhong Liu Za Zhi 2001
(Nasopharyngeal Neoplasms) :
Overexpression of either
TRAF1 , 3 or an dominant negative mutant of TRAF1, 3
inhibited the expression of
EGFR , while TRAF2 or negative mutants of TRAF2 did slightly so
Miller et al., Mol Cell Biol 1998
:
In vivo analyses of the interaction of the TRAFs with LMP1 variants mutated in the PXQXT domain indicate that high-level induction of
EGFR expression
requires interaction with
TRAF1 , -2, and -3 ... These data suggest that
TRAF mediated activation of
EGFR expression requires assembly of a complex containing the appropriate stoichiometry of TRAF proteins clustered at the cell membrane with LMP1