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EGF — TYR

Text-mined interactions from Literome

Holbrook et al., Biochemistry 1999 : This reduction in internalization rate increases the lifetime of the activated EGFr in the plasma membrane by about 70 %, thus suggesting that phosphorylation of Tyr992 acts to increase the signaling capacity of the EGF receptor even as it directly acts as an SH2 binding site
Cunnick et al., J Biol Chem 2001 : We found that both Tyr-627 and Tyr-659 of Gab1 were required for SHP2 binding to Gab1 and for ERK2 activation by EGF
Mazière et al., Free Radic Biol Med 2003 : Furthermore, the highest dose of UVA ( 9 J/cm ( 2 ) ) prevented the EGF induced Tyr-phosphorylation of the EGF-receptor (EGF-R)
Sekiya et al., J Biol Chem 2004 : PDGF and EGF induced similar levels of phosphorylation of Tyr-783 and of Tyr-1253 in a cell line that expressed receptors for both growth factors
Rescan et al., Lab Invest 2005 (MAP Kinase Signaling System) : Stimulation of the duct cells with epidermal growth factor (EGF) and betacellulin results in Tyr-phosphorylation of ErbB1 and ErbB2, followed by activation of Shc, MEK1/2 and ERK1/2
Kansra et al., Mol Pharmacol 2005 : Studying normal human keratinocytes ( NHKs ), here we demonstrate strong expression of the Src family kinases Src, Yes, and Fyn ; Src family kinase dependent stimulation of Tyr 845 by EGF ; and potent inhibition of NHK proliferation and migration by two Src family kinase inhibitors PP1 and PD173952
Huckle et al., Mol Cell Biol 1990 : Loading cells with the intracellular Ca2+ chelator bis- ( o-aminophenoxy ) ethane-N, N, N ', N'-tetraacetic acid ( BAPTA ) inhibited the appearance of all P-Tyr-proteins in response to angiotensin II, thapsigargin, or ionophores, as well as two EGF stimulated P-Tyr-proteins ... The majority of EGF stimulated P-Tyr-proteins were not affected by BAPTA
Harris et al., Molecular vision 2007 : Western blots were used to analyze the time dependent effect of EGF on phosphorylation of EGFR Tyr992 plus or minus CinnGEL 2Me, an inhibitor of PTP1B activity
Itoh et al., J Cell Sci 2008 : Intriguingly, EGF stimulation induced phosphorylation of Tyr94 within the APC binding region of Asef in a manner dependent on Src-family tyrosine kinases
Bottomley et al., J Biol Chem 2009 (Hyperlipoproteinemia Type II) : Further, we determined the structures of EGF ( AB ) bound to PCSK9DeltaC containing the FH-associated D374Y and D374H mutations, revealing additional interactions with EGF ( A ) mediated by Tyr-374/His-374 and providing a rationale for their disease phenotypes
Lorita et al., Growth Factors 2009 (Ischemia) : In perfused mouse hearts, EGF induced Tyr-phosphorylation of ErbB1 but not ErbB2
Clayton et al., Mol Pharmacol 2010 : Tyrosine kinase activation by epidermal growth factor (EGF) or hydrogen peroxide treatment effectively increased phosphorylation of the tyrosine-166 in the mu-opioid receptor ( MOR-Tyr166p ) as measured by a novel phosphoselective antibody
Liu et al., Oncogene 2010 (Prostatic Neoplasms) : Small interfering RNA mediated knockdown of Ack1 or Src showed that Ack1 mediates heregulin- and Gas6 induced AR Tyr-267 phosphorylation, whereas Src mediates Tyr-534 phosphorylation induced by EGF , IL-6 and bombesin ... Dasatinib, a Src inhibitor, blocked EGF induced Tyr-534 phosphorylation ... Interestingly, Ack1 or Src knockdown or dasatinib did not inhibit EGF induced AR Tyr-267 phosphorylation or EGF stimulated AR activity, suggesting the existence of an additional tyrosine kinase that phosphorylates AR at Tyr-267
Ishii et al., FEBS Lett 2012 : Ubiquitination of the C-terminal region of SPE-39 was also elevated in response to EGF stimulation, and this process was regulated by the phosphorylation of Tyr-11 in SPE-39
Song et al., J Mol Cell Cardiol 2012 : Phosphorylation of Tyr-925 of FAK in response to EGF was significantly reduced in KO cell compared to WT cells
Jiang et al., PloS one 2013 (Stomach Neoplasms) : PKG II inhibited EGF induced migration activity and blocked EGF initiated signal transduction of PLC?1 and MAPK/ERK mediated pathways through preventing EGF induced Tyr 992 and Tyr 1068 phosphorylation of EGFR
Westendorf et al., J Biol Chem 1983 (Neoplasms, Experimental...) : However, binding of [ 125I-Tyr4 ] bombesin was not inhibited by 100 nM thyrotropin releasing hormone, vasoactive intestinal peptide, epidermal growth factor , or somatostatin
Zhou et al., J Biol Chem 1994 (Carcinoma, Squamous Cell) : Findings i and ii above indicate that GM3 directly inhibits EGF dependent Tyr phosphorylation but does not affect receptor-receptor interaction
Shin et al., Life Sci 1994 : Substituting Tyr with Phe at position 's 37 and 13 had little effect on the mitogenic activity of h-EGF
Malecka-Panas et al., Carcinogenesis 1996 : To assess the functional role of TGF-alpha in colonic carcinogenesis the present investigation examines the changes in TGF-alpha-and EGF induced activation of intrinsic tyrosine kinase (Tyr-k) activity of EGFR in the colonic mucosa of rats after administration of the colonic carcinogen azoxymethane ( AOM ; 20 mg/kg body wt )