◀ Back to SYT1
SYT1 — VAMP2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Effects of Botulinum toxin:
STX1A/SNAP25/VAMP2 complex (STX1A-SNAP25-VAMP2)
→
ACh/Synaptotagmin 1 complex (SYT1)
(modification, activates)
-
NCI Pathway Database Effects of Botulinum toxin:
STX1A/SNAP25 fragment 1/VAMP2 complex (STX1A-SNAP25-VAMP2)
→
ACh/Synaptotagmin 1 complex (SYT1)
(modification, activates)
-
NCI Pathway Database Effects of Botulinum toxin:
VAMP2 fragments (VAMP2/VAMP2/VAMP2/VAMP2/VAMP2/VAMP2)
→
ACh/Synaptotagmin 1 complex (SYT1)
(modification, inhibits)
-
Reactome Reaction:
SYT1
→
VAMP2
(direct_complex)
Takamori et al., Nature 2000*, Seal et al., Neuron 2008*, Erickson et al., J Biol Chem 1994*
-
Reactome Reaction:
SYT1
→
VAMP2
(reaction)
Augustin et al., Nature 1999, Takamori et al., Nature 2000*, Deken et al., Nat Neurosci 2000, Barclay et al., J Biol Chem 2003, Gasnier et al., Pflugers Arch 2004, Toonen et al., J Neurochem 2005, Quick et al., Handb Exp Pharmacol 2006, Dulubova et al., Proc Natl Acad Sci U S A 2007, Martens et al., Science 2007, Stein et al., Nature structural & molecular biology 2007, Khvotchev et al., J Neurosci 2007, Seal et al., Neuron 2008*, Binda et al., Mol Pharmacol 2008, Koch et al., Curr Opin Neurobiol 2009, Riento et al., J Cell Sci 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Shin et al., Neuron 2003
(Calcium Signaling...) :
Thus, triggering of the fast component of release by Sr ( 2+ ) as a Ca ( 2+ ) agonist involves the formation of
synaptotagmin/phospholipid complexes, but does not
require stimulated
SNARE binding
Lopez et al., FASEB J 2007
:
Previous studies indicate that the process requires Rab3 dependent tethering of membranes,
SNARE complex assembly, and Ca2+ mediated
activation of
synaptotagmin