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TLR4 — VCAM1
Text-mined interactions from Literome
Sawa et al., J Histochem Cytochem 2008
:
The LPS induced IL-6, IL-8,
VCAM-1 , and ICAM-1 production in LEC was
suppressed by the introduction of TLR4-specific small interfering RNA, and also by
anti-TLR4 , nobiletin, and CAPE pretreatment
Sawa et al., Cell Tissue Res 2008
:
The expression of LTA induced E-selectin, ICAM-1, and
VCAM-1 in LEC is
suppressed by anti-TLR2 but not by
anti-TLR4 and is also suppressed by TLR2-specific short interfering RNA ( siRNA ) but not by siRNA for TLR4
Lee et al., Cell communication and signaling : CCS 2012
:
In bacteria induced glomerulonephritis,
Toll-like receptor 4 (TLR4) activation by lipopolysaccharide ( LPS, a key component of the outer membranes of Gram negative bacteria ) can
increase oxidative stress and the expression of
vascular cell adhesion molecule-1 ( VCAM-1 ), which recruits leukocytes to the glomerular mesangium