Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Gao et al., Toxicol Appl Pharmacol 2004 (Ovarian Neoplasms) : Our results also indicated that the mTOR/FRAP inhibitor, rapamycin, inhibited 4-OHE2 induced HIF-1alpha and VEGF-A expression
Brugarolas et al., Cancer Cell 2004 (Hamartoma...) : However, hypoxia-inducible factor ( HIF ) and VEGF are regulated by mTOR and are likely to play a contributory role
Shiojima et al., J Clin Invest 2005 (Cardiomyopathy, Dilated...) : Enhanced angiogenesis in the acute phase was associated with mammalian target of rapamycin dependent induction of myocardial VEGF and angiopoietin-2 expression
Slomiany et al., J Pharmacol Exp Ther 2006 (Anoxia) : IGF-1 stimulated VEGF promoter activity was phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR ( mammalian target of rapamycin ) -dependent, whereas VEGF secretion was only partially reduced by inhibition of PI3K/Akt/mTOR and HIF-1 activities
Del Bufalo et al., Cancer Res 2006 (Breast Neoplasms...) : A central role for mTOR ( and the critical regulator of cap dependent protein translation, eIF4E ) in the regulation of VEGF production by BT474 cells was further confirmed using a small interfering RNA approach to silence mTOR and eIF4E protein expression
Lee et al., Clin Cancer Res 2006 (Neoplasm Invasiveness...) : In OVCAR-3 and PC-3 cells, the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin/p70S6K and p42/p44 mitogen activated protein kinase pathways were required for LPA induced HIF-1alpha and VEGF expressions, whereas only the phosphoinositide 3-kinase/mammalian target of rapamycin/p70S6K pathway was important in SK-Hep1 cells
Kobayashi et al., Cancer Sci 2007 (Lymphatic Metastasis...) : We investigated the role of mTOR , which is a downstream kinase of the phosphatidylinositol 3-kinase/Akt pathway, and the MAPK family ( MEK1/2, p38, and JNK ) in the regulation of VEGF-C and VEGF-A expression in B13LM cells, a lymphatic metastasis-prone pancreatic tumor cell line
Kurmasheva et al., Mol Cancer Ther 2007 (Anoxia) : Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors ... Rapamycin, a selective inhibitor of mTOR , reduced VEGF production in rhabdomyosarcoma cells under normoxic conditions and partially suppressed hypoxia-driven increases in VEGF
Land et al., J Biol Chem 2007 (Neoplasms...) : Our work shows that activation of mTOR by Ras homologue enriched in brain (Rheb) overexpression potently enhances the activity of HIF1alpha and vascular endothelial growth factor ( VEGF ) -A secretion during hypoxia, which is reversed with rapamycin
Hasaneen et al., Am J Physiol Lung Cell Mol Physiol 2007 : Our results show : 1 ) a significant increase in human lung microvascular endothelial cell ( HMVEC-L ) proliferation, migration, and tube formation following incubation in conditioned media ( CM ) from HASM cells exposed to mechanical strain ; 2 ) mechanical strain of HASM cells induced VEGF expression and release ; 3 ) VEGF neutralizing antibodies inhibited the proliferation, migration, and tube formations of HMVEC-L induced by the strained airway smooth muscle CM ; 4 ) mechanical strain of HASM induced a significant increase in hypoxia-inducible factor-1alpha ( HIF-1alpha ) mRNA and protein, a transcription factor required for VEGF gene transcription ; and 5 ) mechanical strain of HASM induced HIF-1alpha/VEGF through dual phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and ERK pathways
Yang et al., Hepatology 2009 (Liver Neoplasms) : Consistent with this notion, enhanced expression of VEGF-A and activation of Akt/mTOR signaling , comparable to the levels of paired HCC tissues, were also detected in HBV related nontumorous livers
Zheng et al., Cell Biol Int 2009 (Polycystic Kidney, Autosomal Recessive) : Therefore, we investigated the relationship between the decreased FPC and the protein levels of mTOR and the inhibitory effects of rapamycin on the expression of mTOR, Hypoxia-inducible factor-1 alpha ( HIF-1alpha ) and vascular endothelial growth factor ( VEGF ) in the human 293T cell line
Prager et al., Mol Oncol 2010 (Neoplasms) : VEGF ( 165 ) was constantly secreted by all cultured tumor cells in an mTOR dependent manner, as it was inhibited by the mTOR inhibitor rapamycin
Pang et al., Cancer Res 2010 (Neovascularization, Pathologic...) : Celastrol suppressed the VEGF induced activation of AKT, mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase ( P70S6K )
Sun et al., J Pharmacol Exp Ther 2010 (Carcinoma, Adenoid Cystic...) : The data also showed that the specific suppression of tumor angiogenesis by ISL was caused by down-regulation of mammalian target of rapamycin (mTOR) pathway dependent VEGF production by ACC cells, correlating with concurrent activation of c-Jun NH ( 2 ) -terminal kinase ( JNK ) and inhibition of extracellular signal regulated kinase ( ERK )
Calabrò et al., Expert Rev Anticancer Ther 2010 (Carcinoma, Renal Cell...) : The recent emergence of effective molecular targeted therapies, such as antibodies neutralizing VEGF , inhibitors of tyrosine kinase and mTOR inhibitors, has sparked an interest in their use prior to surgical resection of renal cell carcinoma (RCC), a practice commonly used in the treatment of many other advanced solid tumors
Yan et al., J Cell Biochem 2010 : VEGF stimulation results in mTOR signaling activation which changes the phosphorylation status of 4E-BP1, the downstream of mTOR signaling, and ultimately contributes to the translation initiation of Livin protein
Edelstein et al., Cell Signal 2011 (Neuroblastoma) : The RTK for the vascular endothelial growth factor ( VEGF ), VEGFR2, can signal protein synthesis but whether it cooperates with mAchRs to mediate mTOR activation has not been demonstrated
Nakamura et al., Mol Cell Neurosci 2011 : Pharmacologic inhibitors of the Trk tyrosine kinase, PI-3 kinase and mTOR paths prevent NGF stimulated increases in HIF-1a and VEGF
Ikeda et al., Mol Cell Biol 2011 (Disease Models, Animal...) : In cultured lung epithelial cells, insulin reduced VEGF expression and transcriptional activity of HIF-2 on VEGF promoter in an mTOR dependent manner
Aleffi et al., Am J Physiol Gastrointest Liver Physiol 2011 (Neovascularization, Pathologic) : In conclusion, in HSC exposed to leptin or PDGF, increased expression of VEGF requires both activation of mTOR and generation of reactive oxygen species via NADPH-oxidase
Falcon et al., Cancer Res 2011 (Neoplasms, Experimental...) : In this study, we examined the effects of mTORC1/2 dual inhibition on VEGF production, tumor angiogenesis, vascular regression, and vascular regrowth, and we compared the effects of dual inhibition to mTORC1 inhibition alone
Jham et al., PloS one 2011 (Inflammation...) : Conditioned media from vGPCR expressing cells lead to an mTOR dependent increase in HIF-1a and HIF-2a protein levels and VEGF upregulation
Basu et al., PloS one 2011 (Kidney Neoplasms) : We found that the knockdown of raptor ( using siRNA ) significantly decreased CNI induced VEGF promoter activity as observed by promoter-luciferase assay, suggesting the role of mTOR complex1 (mTORC1) in CNI induced VEGF transcription
Joly et al., Bull Cancer 2011 (Carcinoma, Renal Cell...) : The perspectives of renal cell carcinoma (RCC) treatment have improved with the development of targeted molecular therapies against VEGFR/VEGF mediated angiogenesis and mTOR
Pratheeshkumar et al., PloS one 2012 (Neovascularization, Pathologic...) : Western blot analysis showed that quercetin suppressed VEGF induced phosphorylation of VEGF receptor 2 and their downstream protein kinases AKT, mTOR , and ribosomal protein S6 kinase in HUVECs
Lee et al., Neuro Oncol 2012 (Brain Neoplasms...) : The North American Brain Tumor Consortium examined the safety, pharmacokinetics, and efficacy of combination therapy with sorafenib, a small molecule inhibitor of Raf, vascular endothelial growth factor receptor 2, and platelet derived growth factor receptor-ß, and temsirolimus ( CCI-779 ), an inhibitor of mammalian target of rapamycin
Ko et al., Nephrol Dial Transplant 2013 (Disease Models, Animal...) : Experimental deficiency of vascular endothelial growth factor ( VEGF ) induces proteinuria and mTOR is required for VEGF production and signalling
Pratheeshkumar et al., PloS one 2012 (Neoplasm Invasiveness...) : Western blot analysis showed that luteolin suppressed VEGF induced phosphorylation of VEGF receptor 2 and their downstream protein kinases AKT, ERK, mTOR , P70S6K, MMP-2, and MMP-9 in HUVECs
Yang et al., J Biol Chem 2013 (Neoplasms...) : The interaction of Gadd45a with mTOR suppresses STAT3 phosphorylation at Ser-727 and leads to down-regulated expression of VEGFa
Roy et al., Cancer Res 2013 (Disease Models, Animal...) : mTOR blockade reduced VEGF secretion and formation of tumor vasculature