Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Dong et al., Cancer Res 2001 (Carcinoma, Squamous Cell...) : Hepatocyte growth factor/scatter factor induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma ... Inhibitors of MEK ( U0126 ) and PI3K ( LY294002 ) blocked p42/p44 ( erk ) and Akt, respectively, and partially blocked HGF induced production of IL-8 and VEGF , whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A
Huang et al., J Biol Chem 2002 : Phosphatidylinositol 3-kinase is activated by vascular endothelial growth factor ( VEGF ), and many of the angiogenic cellular responses of VEGF are regulated by the lipid products of phosphatidylinositol 3-kinase
Woods et al., Neuro Oncol 2002 (Astrocytoma...) : Phosphatidylinositol 3'-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells
Burroughs et al., Mol Cancer Res 2003 (MAP Kinase Signaling System) : Mutation of the hypoxia response element ( HRE ), which mediates hypoxic stimulation of VEGF transcription, did not inhibit the effect of IGF-I on the VEGF promoter, despite the fact that this mutation inhibited PI3-K stimulated VEGF promoter activity in prostate cancer cells ... These data indicate that PI3-K signaling does not increase VEGF transcription through transactivation by HIF-1 at the HRE in normal PrEC
Li et al., Brain Res Mol Brain Res 2003 (Amyotrophic Lateral Sclerosis...) : VEGF activated both PI3-K and MAPK activities in mouse NSC34 motor neuron-like cells
Zhang et al., J Biol Chem 2003 : Phosphorylation of VEGFR2 at Tyr-801 and Tyr-1175, the critical sites for VEGF induced PI3K-Akt signaling, was not involved in TNF mediated Akt activation ... Taken together, our data demonstrated that TNF induces transactivation between Etk and VEGFR2, and Etk directly activates PI3K-Akt angiogenic signaling independent of VEGF induced VEGFR2-PI3K-Akt signaling pathway
Giuliani et al., Leukemia 2004 (Multiple Myeloma...) : Moreover, we also found that the PI3K kinase inhibitors, but not p38 MAPK inhibitors, reduced VEGF secretion by myeloma cells and increase the inhibitory effect of MEK1 inhibitors
Huang et al., World J Gastroenterol 2004 (Carcinoma, Hepatocellular...) : Effects of PI3K and p42/p44 MAPK on overexpression of vascular endothelial growth factor in hepatocellular carcinoma
Flaxenburg et al., J Immunol 2004 : Also, wortmanin and a dominant-inhibitory mutant of PI3K inhibited CD40 induced overexpression of VEGF
Hellwig-Bürgel et al., Cell Physiol Biochem 2005 : Thus, PI3K signaling is required for HIF-1alpha accumulation and VEGF synthesis, whereas MAPKK-1 signaling is required for VEGF synthesis only
Trisciuoglio et al., Mol Biol Cell 2005 (MAP Kinase Signaling System...) : Involvement of PI3K and MAPK signaling in bcl-2 induced vascular endothelial growth factor expression in melanoma cells
Lee et al., Mol Pharmacol 2006 (Asthma...) : This study aimed to determine the effect of PI3K inhibitors and PTEN on VEGF expression in allergen induced airway inflammation
Wood et al., J Cell Biol 2006 : In contrast, using both laser ablation and a novel wounding assay that allows localized treatment with inhibitory drugs, we show that PI3K is essential for hemocyte chemotaxis toward wounds and that Pvf signals and PDGF/VEGF receptor expression are not required for this rapid chemotactic response
Slomiany et al., J Pharmacol Exp Ther 2006 (Anoxia) : IGF-1 stimulated VEGF promoter activity was phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR ( mammalian target of rapamycin ) -dependent, whereas VEGF secretion was only partially reduced by inhibition of PI3K/Akt/mTOR and HIF-1 activities
Tang et al., Mol Cancer Res 2006 (Breast Neoplasms...) : Furthermore, the PI3K-specific inhibitor LY294002 inhibited VEGF production by EMMPRIN overexpressing cells in a dose- and time dependent manner
Li et al., Int J Mol Med 2006 : Further, we found that PI3K inhibitors, LY294002 and Wortmannin, inhibited HIF-1alpha and VEGF expression induced by UV radiation
Kang et al., Oncogene 2008 (Neovascularization, Pathologic...) : Our results show that N-myc plays an important role in the PI3K mediated VEGF regulation in NB cells
Banerjee et al., Biochemistry 2008 (Breast Neoplasms) : Neutralization of VEGF action by its antibody or inhibition of VEGF induced PI3K/Akt kinase activation by wortmannin, a PI3K/Akt specific inhibitor, results in inhibition of VEGF induced hAOSMC migration
Lu et al., Microvasc Res 2009 (Lung Neoplasms...) : Furthermore, lenalidomide inhibited VEGF induced PI3K-Akt pathway signaling, which is known to regulate adherens junction formation
Guo et al., Stroke 2009 : In contrast, neither inhibition of GSK-3beta nor inhibition of PI3-K had any detectable effects on VEGF levels in astrocytes
García-Maceira et al., Oncogene 2009 (Carcinoma, Hepatocellular) : Moreover, silibinin reduced hypoxia induced vascular endothelial growth factor ( VEGF ) release by HeLa and Hep3B cells, and this effect was potentiated by the PI3K/Akt inhibitor LY294002
Yang et al., Invest Ophthalmol Vis Sci 2009 (Anoxia...) : Role of PI3K/Akt and MEK/ERK in mediating hypoxia induced expression of HIF-1alpha and VEGF in laser induced rat choroidal neovascularization ... A well established rat model of CNV and cultured human retinal pigment epithelium ( hRPE ) was used to investigate the role of PI3K/Akt and MEK/ERK pathways in regulating HIF-1alpha and VEGF expression in CNV in rat and hRPE under hypoxia by immunohistochemistry, Western blot analysis, real-time PCR, and ELISA
Lu et al., Am J Respir Cell Mol Biol 2010 (Neovascularization, Pathologic...) : Activation of PI3K/Akt by bleomycin also led to transcriptional activation and protein expression of hypoxia-inducible factor-1alpha ( HIF-1alpha ) and vascular endothelial growth factor , which contributed to the fibroproliferative and collagen inducing effects of bleomycin
Jiang et al., Adv Cancer Res 2009 (Neoplasms...) : PI3K signaling regulates tumor growth and angiogenesis by activating AKT and other targets, and by inducing HIF-1 and VEGF expression
Dai et al., Oncogene 2009 : In turn, OPN induced VEGF activates PI3K/AKT and the ERK1/2 pathway as a positive feedback signal
Elayappan et al., Angiogenesis 2009 : Of interest, PEDF effectively abrogated VEGF mediated phosphorylation of PI3K/Akt
Westra et al., Ann N Y Acad Sci 2009 (Arthritis, Rheumatoid) : Protein and mRNA expression of HIF-1alpha and the effects of inhibitors of the CaMKII-, PI3K- , and ERK pathway on VEGF and IL-6 production were analyzed
Chetty et al., Int J Cancer 2010 (Lung Neoplasms) : We also show that MMP-2 suppression disrupted PI3K dependent VEGF expression ; ectopic expression of myr-AKT restored VEGF inhibition
Westra et al., BMC musculoskeletal disorders 2010 (Arthritis...) : THP-1 and SF macrophages produced high levels of VEGF, IL-8, and MMP-9, and VEGF protein production was significantly inhibited by PI3K-inhibitor , and by both CaMKII inhibitors
Lee et al., FEBS Lett 2010 : We demonstrate that reduction in Ca ( 2+ ) by chelating compound BAPTA-AM or by IP ( 3 ) -endoplasmic reticulum blocker 2-APB selectively inhibited VEGF induced activation of c-Src-PI3K-Akt but not ERK1/2 in human coronary artery endothelial cells ( HCAEC ) ... We also show that the selective inhibitory effects of NADPH oxidase knockdown on VEGF mediated activation of c-Src-PI3K-Akt signaling and cell proliferation in HCAEC can be reversed by increase in intracellular Ca ( 2+ )
Jang et al., BMC cancer 2010 (Breast Neoplasms...) : Inhibition of PI3K/Akt signaling by ANT2 shRNA caused down-regulation of membrane-type 1 matrix metalloproteinase ( MT1-MMP ) and vascular endothelial growth factor ( VEGF ) expression, decreased matrix metalloproteinase 2 (MMP2) and MMP9 activity, and suppressed migration and invasion of breast cancer cells
Luangdilok et al., Eur J Cancer 2011 (Carcinoma, Squamous Cell...) : In both cell lines stimulated with endogenous or exogenous ligand, inhibition of MEK1/2 ( with U0126 or PD98059 ) or PI3K ( with PI-103 or LY294002 ) resulted in a marked reduction of EGFR induced VEGF-A expression, whereas exogenous EGF induced VEGF-C upregulation was blocked by inhibitors of MEK but not PI3K
Yu et al., Cancer Chemother Pharmacol 2011 (Carcinoma, Non-Small-Cell Lung...) : The PI3 K or ERK inhibitors also attenuated expression of VEGF and MMP-9
Yin et al., J Mol Med (Berl) 2011 (Disease Models, Animal...) : PI3K inhibitor LY294002 significantly attenuated Rg1 enhanced VEGF expression and capillary density
Li et al., Zhongguo Dang Dai Er Ke Za Zhi 2011 (Neuroblastoma) : The synthesis and secretion of VEGF can be inhibited by blocking TrkB-BDNF signal pathway with K252a or blocking the TrkB-BDNF downstream signal pathway PI3K/Akt with LY294002
Lee et al., Mol Cells 2011 (Breast Neoplasms) : Moreover, the higher production of vascular endothelial growth factor ( VEGF ) in TAMR-MCF-7 cells was significantly diminished by suppression of PI3K or p38 kinase
Ghosh et al., J Biol Chem 2012 (MAP Kinase Signaling System...) : Therefore, based on these observations, it is hypothesized that the activation of PI3K/AKT and p38 MAPK by VEGF results in ETS-1 gene expression, which activates MMP-9 and MMP-13, leading to the invasion and scattering of SKOV-3 cells
Ruan et al., EMBO J 2012 : Axl is essential for VEGF-A dependent activation of PI3K/Akt ... These results elucidate the mechanism by which VEGF-A activates PI3K/Akt , and identify previously unappreciated potential therapeutic targets of VEGF-A-driven processes
Xu et al., PloS one 2012 (Liver Neoplasms) : Addition of recombinant human VEGF attenuated the inhibitory effects of PP on PI3K/AKT pathway and the cancer phenotypes
Chen et al., Mol Nutr Food Res 2012 : Moreover, lycopene attenuated VEGF receptor-2 (VEGFR2) mediated phosphorylation of extracellular signal regulated kinase ( ERK ), p38, and Akt as well as protein expression of PI3K
Poettler et al., Thromb Haemost 2012 : Thus, VEGF165, VEGF-E , FGF-2, EGF as well as HGF induced a PI3k dependent activation of pro-uPA when bound to uPAR, which led to an increase in cell surface fibrinolytic activity
Piccolo et al., J Mol Med (Berl) 2013 (Breast Neoplasms...) : Production of VEGF , that was restored by exposure of silenced cells to recombinant LGALS3BP, required an intact PI3k/Akt signaling
Genini et al., PloS one 2012 (Carcinoma, Non-Small-Cell Lung...) : Induction of VEGF was due to both binding of PPARß/d to the VEGF promoter and PI3K activation through a non-genomic mechanism
Jang et al., Br J Pharmacol 2013 (Wounds, Penetrating) : Both an AMPK inhibitor ( compound C ) anda HO-1 activity inhibitor ( SnPPIX ) but not inhibitors of MAPKs, PI3K and PKC reduced the production of VEGF by CKD712
Bhattacharya et al., J Neurooncol 2013 (Brain Neoplasms...) : T11TS therapy in rodent glioma model significantly downregulated expression of VEGF along with its receptor VEGFR-2 and inhibited the expression of pro-survival PI3K/Akt/eNOS proteins in glioma associated brain endothelial cells
Lo et al., International journal of molecular sciences 2013 : In parallel, VEGF induced JNK, PI3K and Akt activation
Sun et al., PloS one 2013 : Our results show that baicalein induced Epo and VEGF expression in a HIF1a- and PI3K/Akt dependent manner in neurons