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AKT3 — VIM
Text-mined interactions from Literome
Strizzi et al., J Cell Sci 2005
(Mammary Neoplasms, Animal) :
Treating EpH4/Cripto-1 or HC-11/Cripto-1 mammary cells with exogenous soluble Netrin-1 resulted in increased expression of E-cadherin and UNC5H1, decreased expression of
vimentin and decreased
activation of
Akt as determined by western blotting
Zhu et al., Oncogene 2011
(Neoplasm Invasiveness...) :
The binding of
AKT ( tail region ) to Vim ( head region )
results in
Vim Ser39 phosphorylation enhancing the ability of Vim to induce motility and invasion while protecting Vim from caspase induced proteolysis
Lian et al., J Biol Chem 2012
:
Furthermore, inhibition of
PI3K/Akt/mTOR signaling, but not canonical Smad signaling, downstream of TGFß,
blocked TGFß induced synthesis of
vimentin , and inhibited ATF4 dependent Ocn transcription in osteoblasts