Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Rosner et al., Mutat Res 2008 (Alzheimer Disease...) : Recently, it has been recognized that mTOR is regulated by TNF-alpha and Wnt , both of which have been shown to play critical roles in the development of many human neoplasias
Fujishita et al., Proc Natl Acad Sci U S A 2008 (Adenoma...) : These results suggest that the Wnt signaling contributes to mTORC1 activation through the increased level of mTOR and that the activation plays important roles in the intestinal polyp formation and growth
Ma et al., J Neurosci 2011 (Wnt Signaling Pathway) : Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3
Liu et al., J Biol Chem 2012 (Diabetes Mellitus, Type 2...) : Brown adipose tissue insulin sensitivity and reduced adiposity of LRP6 ( +/- ) mice were accounted for by diminished Wnt dependent mTORC1 activity and enhanced expression of brown adipose tissue PGC1-a and UCP1
Kumar et al., Carcinogenesis 2012 (Colonic Neoplasms...) : Further, a combination regime of SDs and low-dose rapamycin decreased visible polyps in Apc ( Min/+ ) mice and reduced the levels of Wnt target gene expression and mTOR target activation