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PARP1 — XRCC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PARP1 — XRCC1 (physical association, affinity chromatography technology) Leppard et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: PARP1 — XRCC1 (physical association, affinity chromatography technology) Gueven et al., Hum Mol Genet 2004*
• IRef Biogrid Interaction: PARP1 — XRCC1 (direct interaction, two hybrid) Masson et al., Mol Cell Biol 1998*
• IRef Biogrid Interaction: PARP1 — XRCC1 (direct interaction, pull down) Masson et al., Mol Cell Biol 1998*
• IRef Biogrid Interaction: PARP1 — XRCC1 (physical association, affinity chromatography technology) Cazzalini et al., DNA repair 2010*
• IRef Biogrid Interaction: PARP1 — XRCC1 (physical association, affinity chromatography technology) Lee et al., Molecular cancer 2010*
• MIPS CORUM Condensin I-PARP-1-XRCC1 complex: Condensin I-PARP-1-XRCC1 complex complex (NCAPD2-NCAPG-NCAPH-PARP1-SMC2-SMC4-XRCC1) Heale et al., Mol Cell 2006
• IRef Corum Interaction: Complex of NCAPH-XRCC1-SMC4-SMC2-PARP1-NCAPD2-NCAPG (association, anti bait coimmunoprecipitation) Heale et al., Mol Cell 2006
• IRef Hprd Interaction: PARP1 — XRCC1 (in vivo) El-Khamisy et al., Nucleic Acids Res 2003*, Date et al., Biochem Biophys Res Commun 2004*, Masson et al., Mol Cell Biol 1998*
• IRef Hprd Interaction: PARP1 — XRCC1 (two hybrid) El-Khamisy et al., Nucleic Acids Res 2003*, Date et al., Biochem Biophys Res Commun 2004*, Masson et al., Mol Cell Biol 1998*
• IRef Hprd Interaction: Complex of PARP1-XRCC1-LIG3-PARP1-LIG3-LIG3-XRCC1-PARP1-XRCC1 (in vivo) Leppard et al., Mol Cell Biol 2003*
• IRef Intact Interaction: XRCC1 — PARP1 (physical association, anti tag coimmunoprecipitation) Chou et al., EMBO J 2008*
• IRef Intact Interaction: Complex of 12 proteins (association, pull down) Kanno et al., EMBO J 2007
• IRef Intact Interaction: Complex of 25 proteins (association, anti bait coimmunoprecipitation) Gueven et al., Hum Mol Genet 2004*
• IRef Intact Interaction: Complex of NCL-APTX-PARP1-TP53-XRCC1 (association, pull down) Gueven et al., Hum Mol Genet 2004*
• IRef Ophid Interaction: XRCC1 — PARP1 (aggregation, confirmational text mining) El-Khamisy et al., Nucleic Acids Res 2003*
• IRef Ophid Interaction: XRCC1 — PARP1 (aggregation, confirmational text mining) Masson et al., Mol Cell Biol 1998*
• IRef Ophid Interaction: XRCC1 — PARP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Godon et al., Nucleic Acids Res 2008 : PARP-1 inhibition prevented XRCC1-YFP recruitment at sites of 405 nm laser micro irradiation, slowed SSBR 10-fold and triggered the accumulation of large persistent foci of GFP-PARP-1 and GFP-PCNA at photo damaged sites
Ström et al., Nucleic Acids Res 2011 : Interestingly, we uncover a synthetic lethality between XRCC1 deficiency and PARP inhibition
Campalans et al., Nucleic Acids Res 2013 : We show first that XRCC1 recruitment to BER is independent of PARP