Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
YWHAB
→
PRKCZ
(directlyIncreases, YWHAB Activity)
Van Der Hoeven et al., Biochem J 2000 Evidence: Together, the results suggest that 14-3-3 binds both PKC-zeta (at phospho-Ser-186) and Raf-1 in a ternary complex. Phosphorylation of 14-3-3beta by PKC-zeta negatively regulated their physical association. 14-3-3beta with its putative PKC-zeta phosphorylation sites mutated enhanced co-precipitation between PKC-zeta and Raf-1, suggesting that phosphorylation of 14-3-3 by PKC-zeta weakens the complex in vivo. We conclude that 14-3-3 facilitates coupling of PKC-zeta to Raf-1 in an isotype-specific ...
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *