Description
This track shows conserved mammalian microRNA regulatory target sites in
the 3' UTR regions of Refseq Genes, as predicted by TargetScanS.
Method
Putative miRNA binding sites on mRNAs were identified using six-nucleotide
seed sequences from all known miRNAs conserved among human, mouse, rat,
dog and chicken. These seed sequences were probed against the 3' end
of mRNAs conserved over the five genomes.
For further details of the methods used to generate
this annotation, see Lewis et al. (2005).
Credit
Thanks to Benjamin Lewis at MIT and the Whitehead
Institute for providing this annotation.
Additional information on microRNA target
prediction is available on the
TargetScan website.
References
Lewis BP, Burge CB, Bartel DP.
Conserved seed pairing, often flanked by adenosines, indicates
that thousands of human genes are microRNA targets.
Cell. 2005 Jan 14;120(1):15-20.
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