Description

MyCancerGenome is a personalized cancer medicine knowledge resource for physicians, patients, caregivers and researchers curated at the Vanderbilt-Ingram Cancer Center. My Cancer Genome gives up-to-date information on what mutations make cancers grow and related therapeutic implications, including available clinical trials.

Variants are mapped to the genomic location. Gene-level data is mapped to the location of the RefSeq transcript of the gene.

Display conventions

This is a "sparse" track, with 462 features. The most annotated genes are: PR 0.216% ZRSR2 0.216% SF3B1 0.216% ETV6 0.216% BCOR 0.216% U2AF1 0.216% ER 0.216% FGFR3 0.216% DDR2 0.216% STAG2 0.216% NTRK1 0.216% AR 0.216% ESR1 0.216% TP53 0.216% TET2 0.216% BIRC3 0.216% SRSF2 0.216% RUNX1 0.216% RICTOR 0.216% FGFR2 0.216% ASXL1 0.216% TSC1 0.216% EZH2 0.216% ROS1 0.216% MET 0.433% DEK-NUP214 0.433% RBM15-MKL1 0.433% MLL-MLLT3 0.433% RUNX1-RUNX1T1 0.433% FGFR1 0.433% AKAP-BRAF 0.433% PML-RARA 0.433% NF1 0.433% CRLF2 0.433% NOTCH1 0.433% AKT1 0.649% RPN1-EVI1 0.866% CBFB-MYH11 0.866% RET 0.866% JAK2 0.866% GNA11 0.866% GNAQ 0.866% CTNNB1 1.082% HRAS 1.082% PDGFRA 1.082% DNMT3A 1.515% SMAD4 1.732% IDH1 2.381% SMO 2.381% MEK1 2.381% IDH2 2.814% HER2 2.814% EGFR 2.814% PTEN 3.030% FLT3 3.030% ALK 3.896% KIT 6.277% PIK3CA 7.792% BCR-ABL1 7.792% BRAF 8.658% NRAS 8.658% KRAS 12.987%

Fusion genes are mapped to the gene locations of both genes of the fusion.

Seemingly duplicate entries are the result of the same variant being annotated for different cancer types. This is due to the current export format of MyCancerGenome and may be solved in the future.

Data access

Credits

References

"My Cancer Genome: Web-based clinical decision support for genome directed lung cancer treatment" MA Levy, CM Lovly, L Horn, R Naser, W Pao, J Clin Oncol, 29, 2011