This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Description
The RefSeq Genes track shows known human protein-coding and
non-protein-coding genes taken from the NCBI RNA reference sequences
collection (RefSeq). The data underlying this track are updated weekly.
Please visit the Feedback for Gene and Reference Sequences (RefSeq) page to
make suggestions, submit additions and corrections, or ask for help concerning
RefSeq records.
For more information on the different gene tracks, see our Genes FAQ.
Display Conventions and Configuration
This track follows the display conventions for
gene prediction tracks.
The color shading indicates the level of review the RefSeq record has
undergone: predicted (light), provisional (medium), reviewed (dark).
The item labels and display colors of features within this track can be
configured through the controls at the top of the track description page.
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- Codon coloring: This track contains an optional codon coloring
feature that allows users to quickly validate and compare gene predictions.
To display codon colors, select the genomic codons option from the
Color track by codons pull-down menu. For more information about this
feature, go to the
Coloring Gene Predictions and Annotations by Codon page.
- Hide non-coding genes: By default, both the protein-coding and
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Methods
RefSeq RNAs were aligned against the human genome using BLAT. Those
with an alignment of less than 15% were discarded. When a single RNA
aligned in multiple places, the alignment having the highest base identity
was identified. Only alignments having a base identity level within 0.1% of
the best and at least 96% base identity with the genomic sequence were kept.
Credits
This track was produced at UCSC from RNA sequence data generated by scientists
worldwide and curated by the NCBI
RefSeq project.
References
Kent WJ.
BLAT - the BLAST-like alignment tool.
Genome Res. 2002 Apr;12(4):656-64.
PMID: 11932250; PMC: PMC187518
Pruitt KD, Brown GR, Hiatt SM, Thibaud-Nissen F, Astashyn A, Ermolaeva O, Farrell CM, Hart J,
Landrum MJ, McGarvey KM et al.
RefSeq: an update on mammalian reference sequences.
Nucleic Acids Res. 2014 Jan;42(Database issue):D756-63.
PMID: 24259432; PMC: PMC3965018
Pruitt KD, Tatusova T, Maglott DR.
NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins.
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D501-4.
PMID: 15608248; PMC: PMC539979
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