◀ Back to IGF2
IGF2 — IRS2
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
IRS2
→
IGF2
(reaction)
Karas et al., Endocrinology 2001, Schreyer et al., Endocrinology 2003, Kim et al., Oncogene 2004, Rakatzi et al., Arch Physiol Biochem 2006, Cuevas et al., J Hepatol 2007, Siemeister et al., J Biol Chem 1995, Xu et al., J Biol Chem 1995, He et al., J Biol Chem 1996*, Takahashi et al., Endocrinology 1997, Fantin et al., J Biol Chem 1998, Kim et al., Endocrinology 1998, Kim et al., J Biol Chem 1998
-
Reactome Reaction:
IRS2
→
IGF2
(indirect_complex)
Karas et al., Endocrinology 2001, Schreyer et al., Endocrinology 2003, Kim et al., Oncogene 2004, Rakatzi et al., Arch Physiol Biochem 2006, Cuevas et al., J Hepatol 2007, Siemeister et al., J Biol Chem 1995, Xu et al., J Biol Chem 1995, He et al., J Biol Chem 1996*, Takahashi et al., Endocrinology 1997, Fantin et al., J Biol Chem 1998, Kim et al., Endocrinology 1998, Kim et al., J Biol Chem 1998
Text-mined interactions from Literome
Rui et al., J Biol Chem 2001
(Carcinoma, Hepatocellular...) :
In this study, we show that insulin,
IGF-1 , or osmotic stress
promoted ubiquitin/proteasome mediated degradation of
IRS-2 in 3T3-L1 cells, Fao hepatoma, cells and mouse embryo fibroblasts ; however, insulin/IGF-1 did not promote degradation of IRS-1 in 3T3-L1 preadipocytes or mouse embryo fibroblasts
Vincent et al., Neurobiol Dis 2004
:
IGF-I :
IGF-IR signaling
involves phosphorylation of IRS-1 and Shc, but not
IRS-2
Boissan et al., Am J Pathol 2005
(Carcinoma, Hepatocellular...) :
The functionality of IRS-2 was demonstrated in Hep 3 B cells, in which
IRS-2 tyrosine phosphorylation and its association with phosphatidylinositol-3 kinase were
induced by
IGF-2
Kim et al., Endocrinology 2005
(Neuroblastoma) :
In summary, 1 )
IRS-2 is more sensitive to IGF-I mediated degradation ; 2 ) IRS degradation is mediated by phosphatidylinositol 3-kinase and proteasome sensitive pathways ; and 3 ) high levels of
IGF-IR , and possibly the subsequent increase in Akt phosphorylation, are
required for efficient IRS degradation
Barnes et al., Clin Cancer Res 2007
(Head and Neck Neoplasms) :
Pretreatment of serum starved 183A or TU159 SCCHN cell lines with A12 ( 10 microg/mL ) blocked
IGF stimulated activation of IGF-IR, insulin receptor substrate (IRS)-1 and
IRS-2 , mitogen activated protein kinase, and phosphatidylinositol 3-kinase
Heckman et al., Dev Biol 2007
:
Because both
IGF and p190-B signaling
affect IRS-1/2 , we examined IRS-1/2 double knockout embryonic mammary buds
Simmons et al., Am J Physiol Gastrointest Liver Physiol 2007
:
In contrast,
IGF-I activated both IRS-1 and
IRS-2 in intestinal myofibroblasts and IRS-2 activation was upregulated in IRS-1-null myofibroblasts
Kwon et al., Cancer Res 2009
(Adenocarcinoma...) :
Furthermore, we also showed that insulin receptor substrate
(IRS)-2 , but not IRS-1, is
involved in regulation of
IGF-IR expression, which is most likely not transcriptional control ... Overall, these findings suggest a novel regulatory
role of
IRS-2 on the expression of
IGF-IR through PKCdelta and mTOR in pancreatic cancer cells
Fukushima et al., J Biol Chem 2012
:
In these cells,
IGF-I stimulation
induced tyrosine phosphorylation of IGF-IR and
IRS-1/2 , but mutated IGF-IR failed to bind PI3K and to induce maximal phosphorylation of GSK3ß and cell proliferation in response to IGF-I
Dews et al., Recept Signal Transduct 1997
:
Although the mitogenic function of the
IGF-IR may
require the activation of insulin receptor substrate-1 (IRS-1) or
IRS-2 , an overexpressed IGF-IR is able to protect 32D cells, which lack IRS-1 and IRS-2, from apoptosis caused by Interleukin-3 (IL-3) withdrawal
Kornmann et al., Cancer Res 1998
(Colonic Neoplasms...) :
Insulin,
IGF-I , and IGF-II enhanced the growth of both cell lines,
stimulated tyrosine phosphorylation of
IRS-2 , and increased IRS-2 associated phosphatidylinositol (PI) 3-kinase activity
Kim et al., J Biol Chem 1998
(Neuroblastoma) :
In contrast,
IGF-I induces a transient tyrosine phosphorylation of IRS-2 and an association of
IRS-2 with Grb2